Reference no: EM132486904

You are a clinical immunologist and you are studying B-cells. One day when visiting your lab mouse facility, you notice that someone has torn the labels off of all the cages. Your mouse strains all visually look the same but they each have a homozygous deletion for a different gene.  

You need to identify which gene(s) is(are) knocked out in each mouse so you can label the cages appropriately.  You don't have time to wait for the sequencing results,

 so you decide to look at the B-cells and antibodies instead.

Note: for this question, the amount does not matter, if a homozygous deletion would prevent the formation then they are NOT present, if a homozygous deletion of the gene would not completely prevent formation then they are present. 

For each mouse you measure whether the following are present: antibodies (of any type), IgG antibodies, pro B-cells, immature B-cells, and mature B-cells. What do you expect to see in your mice with the given deleted gene(s)? 

• Artemis
• Igα and Igβ (both are knocked out)
• TDT
• VpreB