Genetics alleles

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1. Natural selection increases the frequency of advantageous (more fit) alleles. When a new allele is first created via mutation, it is at low frequency. Consider the following two cases:

a. A recessive advantageous new allele

b. A dominant advantageous new allele

How does the trajectory of these new alleles differ between these two cases? In your answer, be sure to specifically reference the plots (or parts of plots) above which are relevant to this question.

2. Natural selection also removes less-fit alleles (such as those that cause disease) from a population. Consider the following two cases:

a. A dominant disease allele at low frequency

b. A recessive disease allele at low frequency

How does the effect of selection differ between these two cases? In your answer, be sure to specifically reference the plots (or parts of plots) above which are relevant to this question. Note that the term disease allele can simply refer to the less fit of our two alleles.

3. In humans, brown eyes are dominant to blue eyes. Does this mean that we should expect brown eyed individuals to increase in frequency in the population over time?

Address this question using one of the plots above. You can assume that brown and blue eyed people have equal fitness.

4. Finally, a problem that is not about the simulations:

a. In a haploid population of size 50, there are two alleles that do not differ in fitness. If one of the alleles is present in exactly one copy, what is the probability that it will be lost in the next generation?

Reference no: EM1387949

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