Reference no: EM132865209

QUESTION 1.

The authors of this paper have converted Müller glia into retinal ganglion cells by reducing the expression of what gene?

QUESTION 2

The model used in the paper involves causing retinal injury to mice. Briefly describe the method for inducing this injury.

QUESTION 3

Ptbp1 is found in numerous cell types. What feature of the construct(s) used allowed knockdown of Ptbp1 specifically in Müller glia?

QUESTION 4

Retinal ganglion cells receive visual information from photoreceptors through the bipolar cells and retina amacrine cells, and transmit visual information (as action potentials) to what regions in the brain?

QUESTION 5

Parkinson's disease is associated with the degeneration of what kind of neurons , in what region of the brain ?

QUESTION 6

Briefly describe the role of Oxidopamine (6-OHDA) in the experiment(s) described. What sort of cells does it affect?

QUESTION 7

What is the major function of the enzyme tyrosine hydroxylase?

QUESTION 8

- What feature of the tyrosine hydroxylase-expressing cells in the experimental mouse brains suggests they changed cell type?

- How does it suggest that?

- What cell type were they (probably) originally?

QUESTION 9

What is the clinica significance of dopaminergic neurons in terms of human diseases?

QUESTION 10

What is the significance of ipsilateral and contralateral rotation behavior? What drug(s) are used to induce these behaviors?

Attachment:- Cell trans differentiation.rar