Formation of thickened mucus in the lungs

Assignment Help Biology

Reference no: EM1393243

Question: Cystic fibrosis (CF) is a genetic disease that leads to formation of thickened mucus in the lungs, pancrease, and other organs. In the lungs, the mucus impeads airflow and the removal of particulates leading to infection. These problems result in a decreased lifespan for those with CF.
Most people with CF have a mutation in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene that results in the deletion of the amino acid phenylalanine at position 508 in the primary sequence of the protein (F508del-CFTR).
What types of forces/bonds would likely be disrupted by the deletion of phenylalanine?

Question: Normal CFTR is a transmembrane protein that functions as a chloride channel in the plasma membrane. The mutant protein (F508del-CFTR) does not fold properly, because key molecular contacts are missing due to the absence of phenylalanine 508. Patients homozygous for the F508del-CFTR mutation do not express any normal CFTR. CF patients express the mutant F508del-CFTR protein, but only a very small amount is found in the plasma membrane.
In which subcellular organelles/locations would you expect to find the mutant F508del-CFTR protein? (you may choose more than one answer)
cytoplasm b mitochondria c rough ER d golgi e chloroplast f lysosome

Reference no: EM1393243

Questions Cloud

Find the lower control limit for the control chart : A fast food franchise tracked the number of errors that occurred in customers' orders. These included wrong menu item, wrong size drink, lack of condiments,

Dynamic range of environmental qualities : Explain how does homeostasis maintain a dynamic range of environmental qualities rather than hold the internal environment at a set point?

Explain five aspects of language knowledge : Explain the five aspects of language knowledge (phonetic, semantic, syntactic, morphemic, and pragmatic) and describe your role in explaining each of these areas.

What is the upper control limit : Before shipping lawn mowers to dealers, an inspector attempts to start each mower and notes any that do not start on the first try. The lot size is 21 mowers

Formation of thickened mucus in the lungs : Cystic fibrosis is a genetic disease that leads to formation of thickened mucus in the lungs, pancrease, and other organs. In the lungs, the mucus impeads airflow and the removal of particulates leading to infection.

Power point on freedom of speech controversy in social media : We require to do 10-14 PowerPoint. It has to be on Freedom of speech controversy in Social Media. These are the questions we have to cover. The issue itself and why it caused controversy.

Quality management promoted the quality trilogy : Which leader in quality management promoted the Quality Trilogy of quality planning, quality control, and quality improvement?

Find probability of obtaining a pink offspring : Assume that flower color is inherited by simple dominance and that red flowers are dominant to white flowers.

Mixed integer problem-formulation and solution : Lauren Moore has sold her business for $500,000 and wants to invest in condominium units ( which she intends to rent) and land ( which she will lease to a farmer).

User Account

All Pages