Find which snps are linked to the gene

Assignment Help Biology

Reference no: EM1386726

Suppose an analyzer created a purebred strain of these smart mice and started breeding them with other mice to map the gene responsible for the phenotype. After a few generations, she narrowed the locus down to a 10Mb region on Chromosome 4. In order to create a finer map, Ashley picked 10 SNPs from this region. She genotyped 100 smart mice for each of these SNPs. The results are given in the table below. First column is the ID number of the SNP. Second column shows you which nucleotides are possible for that SNP location. Columns 3 and 4 show how many of the smart mice have either genotype. Assume all genotypes are homozygous:

SNP #	Possible genotypes	Smart mice (Total: 100)
1	A or G	A: 20	G: 80
2	T or C	T: 49	C: 51
3	A or T	A: 11	T: 89
4	C or G	C: 67	G: 23
5	A or C	A: 0	C: 100
6	T or C	T: 52	C: 48
7	A or G	A: 95	G: 5
8	T or C	T: 55	C: 45
9	A or T	A: 40	T: 60
10	A or G	A: 15	G: 85

Which SNPs are linked to the gene you are trying to find? Which ones are not? What test do you need to apply to prove this statistically?

Organize the linked SNPs from furthest to closest to the gene of interest.

After narrowing down the location of the gene to a manageable portion of the chromosome, what does Ashley need to do to exactly prove which gene is making the mice smarter and how?

Reference no: EM1386726

Questions Cloud

What is the magnitude of the horizontal force acting on puck : An air puck of mass m1 = 0.30 kg is tied to a string and allowed to revolve in a circle of radius R = 1.0 m on a frictionless horizontal table. The other end of the string passes by a hole in the center of the table, and a mass m2 = 1.20 kg is att..

Advantages and disadvantages of working with multiple tables : Write down the advantages and disadvantages of working with multiple tables? Write an example of situation where multiple tables would be suitable in the application.

Chip has an annual salary and his corporation pay : Chip has an annual salary of $41,000 and his corporation pays him twice a month. Illustrate what is the gross income on each pay check which Chip receives?

Nature of belief and identify beliefs : Recognize a decision about which reasonable minds can disagree and explain the nature of belief and identify the beliefs and values that informed the decision that was made

Find which snps are linked to the gene : Suppose an analyzer created a purebred strain of these smart mice and started breeding them with other mice to map the gene responsible for the phenotype.

How does a walker typically go after n steps : Levy flights- consider a random walk of N steps in one-dimension. suppose that the steps are completely uncorrelated, and that the distribution of step size a is given by phi(a)= k*1/(1+abs(a)^alpha).

Define the six major themes which characterize : Define the six major themes which characterize the mind-sets, attitudes and actions of a successful entrepreneur. Which are most important and explain why? Explain how can they be encouraged and developed?

Devise the operaional definitions you would need : Devise the operaional definitions you would need.What would you say in your instructions to the observers you plan to use?. How might you sample this shopper traffic?

Skewed distribution and normal distribution : If you assume returns follow a normal distribution, which investment would give a better chance of getting at least a $40 million return? Explain how your answer could change if you knew returns followed a skewed distribution instead of a normal d..

User Account

All Pages