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It is determined that the human immune system synthesizes 108 – 1010 antibodies. The portion of a typical active in binding antigen consists of two variable domains each containing 100 amino acids. If every variable domain were separately encoded in the genome but could pair promiscuously, then the number of variable domains that needed to be encoded would be of order of magnitude the square root of the total number of antibodies.
1) How many bases would be required to encode separately all the variable domains?
2) Compare this with the size of the human genome.
It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.
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