Find probability that the fetus has inherited the disease

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Reference no: EM1396484

A microsatellite marker has been found to be linked to a rare autosomal dominant disease in humans and can therefore be used to follow inheritance of the disease allele. The reliability of this microsatellite marker as a predictor of the disease is related to the map distance between the marker and the gene causing the disease. Your patient is a man affected with the disease (genotype Dd) who is heterozygous for the V1 and V2 alleles of the microsatellite marker, with his V1 allele on the same chromosome as his D allele and his V2 allele on the same chromosome as his d allele. His wife is V3V3 dd (V3 is another allele of the microsatellite marker). She is pregnant and is undergoing genetic testing by amniocentesis to predict whether the fetus will have the disease. The results demonstrate that the fetus has the V1 and V3 alleles of the microsatellite marker. What is the probability that the fetus has inherited the disease allele D if the distance between the D locus and the microsatellite marker locus is: (A) 0 map units? (B) 2 map units? (C) 50 map units? Please explain how to do it. I already have the answers for it.

Reference no: EM1396484

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