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A 39-year-old man presented for evaluation of recurrent fractures associated with extensive fibrous dysplasia of bone. His initial fracture occurred at the tibia at age 10 with minimal trauma. During childhood he sustained multiple additional fractures, including:
- His right humerus on four occasions.
- A traumatic right hip fracture in grade school requiring treatment with an intramedullary rod and interlocking screws The patient's puberty started at age 12. Following high school, he noted a gradual increase in facial asymmetry with prominence of his forehead and left check. He denied prior chronic glucocorticoid or anti-epileptic medication use and had no history of nephrolithiasis or hearing loss. The patient had no other known medical comorbidities and was taking no medications.
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What disorder do you suspect the patient is suffering from? What medications and/or procedures might the patient require and why?
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