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The drug warfarin is an anticoagulant that is used after heart surgery to inhibit blood coagulation and diminish the risk of forming dangerous clots. This drug has a very narrow
therapeutic index (i.e. concentration in plasma at which drugs is inhibits major clot formation, but does not prevent basal levels of clotting in response to injury). In plasma, the drug is highly protein bound with 99% found bound to various serum proteins. Individuals on this drug who are exposed to high levels of Polychlorinated Benzene (PCB) pesticides, such as DDT, can suffer severe and life threatening bleeding episodes, where their blood is unable to clot in response to minor injuries. Provide a likely explanation of how PCB exposure could increase the activity of this drug, resulting in an enhanced risk of excessive bleeding episodes (limit 5-6 sentences).
What are disruptive technologies and how do they enable organizations to change their business processes radically? Give a specific example
Assume you have a set of 4-Hfr strains and you carry out a series of crosses with a multiply marked recipient that is auxotrophic for many different nutritional markers.
How would you approach the physician? What are the reasons for the unavailability of certain pharmaceutical items because of third-party payer reimbursement schemes?
In which farm animals is a corpus luteum/corpora lutea necessary throughout gestation to maintain pregnancy? HOw does pregnancy recognition in the cow differ from that of the pig? How do they both differ from pregnancy recognition in cats and dogs?
A stock homozygous for three recessive autosomal genes, a, b,and c, not necessarily linked on the same chromosome, ismated to a stock homozygous for their dominant wild-typealleles. F1 females are then backcrossed to males of thehomozygous recessi..
Compare and contrast the three modes of photosynthesis. List the advantages and disadvantages of each mode.
Rabbits with the genotype CBCB are black, heterozygous rabbits CBCW appear brown, and rabbits that are CWCW have white fur. What is the phenotypic and genotypic ratio of the offspring of a cross between a brown and a white rabbit?
Receptor ligand interactions, the researcher wanted to narrow down exact region of binding between the receptor and the ligand.
In Drosophila, the genes b,c, and sp are linked and in order given, the distancs being b-c=40cM and c-sp= 40cM. These intervals exhibit 75% interference (I=0.75). How many double crossovers would be recovered in a 3-point cross involvng b,c, and sp o..
How has DNA sequencing affected the science of classifying organisms, You are on vacation and see an organism that you do not recognize. Discuss what possible steps you can take to classify it
in 3-5 paragraphs reflect on the history of abortion laws and the recent challenges to these laws in the united states
q. the human circulation flows at the rate of 5 lmin 5 litersmin at a mean constant arterial pressure of 100 mmhg and
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