Explore the regulation and function of pk1

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A genetic screen undertaken in budding yeast has identified a gene whose product encodes a protein kinase that controls the transition of cells from G2 into mitosis. By sequence comparison, you identify a human homologue of the yeast protein, which you name PK1. You now wish to explore the regulation and function of PK1 in cultured human cells.

Firstly you treat the cells with a named drug in order to synchronise them in a specific stage of the cell cycle.

Which stage of the cell cycle would you expect the strongest signal for active PK1 to be observed? Briefly explain why this would be the case.

Reference no: EM133199236

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