Explanation for mechanism that cause the inheritance pattern

Reference no: EM1398095

A man has a heritable disease, which his father suffers from, along with his son. His father's symptoms are comparatively light, where his sons are profound and seen at a much earlier age. What is a good explanation for the mechanism that is causing this inheritance pattern?

trinucleotide repeats are added every generation to a region of DNA
each successive generation gains a new mutation in a different loci on the chromosomes
the mothers do not have the diseases badly because they are females, and are protected from X linked recessive phenotypes because of an XX karyotype
DNA that has gained a mutation is much easier to mutate each successive generation

Reference no: EM1398095

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