Reference no: EM133292831

1. Explain the role(s) of intermediate filaments in the nucleus of a eukaryotic cell?

2. Explain what is the dynamic instability of a microtubule and describe the mechanism. Why this phenomenon beneficial to the cell?

3. In the remodeling of the cytoskeleton, three GTP-ases are very important with regard to the assembly of actin filaments. Name the three GTP-ases, as well as describe their effect on the cytoskeleton when 'active'

4. Describe the mechanism of action of GTPase Ran during a nuclear import cycle. Also include in your answer the proteins that influence the state of the GTPase Ran.

5. An mRNA encoding a lysosomal enzyme is exported from the nucleus through a nuclear pore in order to be translated into protein. Describe the subsequent steps that must occur in order for this protein to arrives at its destination. Include in your answer the organelles that this news will encounter protein during its journey, as well as the changes it must undergo.

6. Name the three types of mitotic spindle microtubules and explain how each type contributes to the segregation of genetic material in anaphase.

7. Define Cdk and describe the mechanisms responsible for the activation of a Cdk.

8. Define APC and explain how it triggers the separation of sister chromatids during mitosis.

9. Describe the mechanism of a nuclear import cycle. Also include in your answer proteins that influence the GTP-GDP state.

10. What type of cytoskeletal proteins play an important role in the nucleus of a eukaryotic cell? Describe this structure and its function?