Explain the neurobiological mechanisms

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1. Explain the neurobiological mechanisms through which cocaine affects neurotransmission, with a focus on its impact on dopamine reuptake. Discuss how cocaine alters dopamine levels in the brain and the role of dopaminergic cells and the dopamine transporter (DAT) in this process.

2. Discuss the role of cannabinoid receptors, specifically CB1 and CB2 receptors, in the central nervous system and their distinct patterns of expression. Explore the mechanisms of action involving Gi/Go proteins when cannabinoids bind to CB1 receptors and the subsequent effects on GABA terminals and dopamine neurons.

Reference no: EM133528409

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