Explain the hypothalamus-pituitary-thyroid axis

Reference no: EM133617827

You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed. (All of these are hypothetical drugs.)

Peroxidine inhibits thyroid peroxidase from functioning.
Cimigine inhibits potassium/iodine cotransporter.
Iodimine inhibits iodinase from functioning.
Aldosine inhibits production of angiotensinogen from the liver.
Aldoramine inhibits sodium/iodine cotransporter.
Thyromine stimulates thyroglobulin production.

1. Describe in detail the steps involved in the synthesis of thyroid hormones (T3 and T4).

2. Explain the hypothalamus-pituitary-thyroid (HPT) axis in relation to thyroid hormone release.

3. Which hypothetical drugs would treat thyroid disease (hyper and hypothyroid) and explain the reasoning behind it.

Reference no: EM133617827

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