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Sickle-Cell anemia is caused by a point mutation in the B-globin chain of hemoglobin. This causes the hydrophilic amino acid, glutamic acid, to be replaced with the hydrophobic amino acid, valine at the sixth position. This causes a change in the protein's folding.
In adults hemoglobin normally consists of four protein subunits: two subunits of beta-globin and two subunits of a protein called alpha-globin, which is produced from another gene called HBA. Each of these protein subunits is attached to an iron-containing molecule called heme. Each heme contains an iron molecule in its center that can bind to one oxygen molecule.
Explain the effect this single mutation has on protein folding and how this leads to the diseases state of Sickle Cell anemia.
Which of the names commonly used to describe the following groups of organisms, represent actual monophyletic groups? 1. Birds (including all feathered tetrapods) 2. Reptiles (including turtles, crocodilians, lizards and snakes)
1). How is the basic functioning of enzymes affected by its shape, active sites and interaction with specific molecules and the environment?
Suppose that a team of scientists exploring in the Amazon discover various novel species of bacteria that use a non-standard nucleotide "X" in DNA.
How can foodborne disease outbreaks be prevented? (whilst working in a restaurant etc)?
Another dog, Billy, has three restriction sites for this enzyme in his genome. For this problem suppose there is only one chromosome in dogs.
Describe the three parts of a flagellum. In addition, identify and describe the various types of flagella arrangements seen in bacterial cells.
Consider two mice that are heterozygous for insulin-like growth factor 2. What genotypic ratio would be expected? What phenotypic ratio would be expected
In a mixed copolymer experiment using polynucleotide phosphorylase, 3/4g:1/4c was used to form synthetic message. the aminoacid was used to form synthetic message.
What are some of the methods of decalcification that are commonly used to remove calcium from calcified tissue?
Phosphonylation, a chemical surface treatment, has been proposed as a means of increasing the hydrophilicity of LDPE, and therefore increase its lubricity and reduce vascular tissue damage.
Describe the process that results in 'cellular suicide'?
Which other species is your creature closely related to. Any surprises. Explain. What are some of the ancestors of your species. Any surprises. Explain
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