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Explain the directed mutation hypothesis (1). Describe an experiment that has tested this hypothesis (2). What was the outcome of this experiment (1)? What did this experiment teach us about how mutation and natural selection interact during evolution (1)?
The coat color in mink is controlled by two codominant alleles at a single locus. Red coat color is produced by the genotype R1R1, silver coat by the genotype R1R2,
Define membrane potential (Vm) and sodium equilibrium potential (ENa). Which of these, if any, changes during the course of an action potential?
Uric acid dissociates with a pKa of 5.80 and can be treated as a simple monoprotic acid in pH range. Its solubility in urine depends on relative amount of protonated and unprotonated forms.
What are RFLPs, VNTRs, and SNPs? What is the relationship among these? How do we use this technology to, for example, identify paternity?
Assume that a particular genetic condition in a mammalian species causes an inability to digest lactose. This disorder occurs with equal frequency in males and females.
Show the structure of sphingosine and indicate the relationship between sphingosine and ceramide.
Living cells are highly ordered units, yet the universe is heading toward higher entropy. Discuss how life can maintain its order in spite of the second law of thermodynamics.
It is January and the starting of a new semester. Just as you get settled in to your new routine, you begin to notice that illness is spreading across campus and other students in your classes are so sick they do not come to virology class.
A group of Ethiopians were assayed for CCR5-del32 deletion polymorphism. 223 were +/+, 64 were +/del32, and 6 were del32/del32.
What is the probability that a daughter will be a carrier? Be prepared to draw a Punnet square on the board.
What is the complementary RNA strand that is created. Assuming this sequence is within an exon and in-frame, what would be the polypeptide formed from it?
DMD is inherited as a sex-linked recessive trait. A couple was surprised to learn that their first child, a son, has DMD since neither of then has the condition. If they have more children, what is the probability for each of heir sons and for eac..
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