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RNA-based viruses such as poliovirus use RNA as their genetic storage material. An important anti-viral drug is ribavirin (see below). RNA polymerase can use ribavirin (the triphosphate version) as a substrate, and it has been suggested that this leads to high mutation rates. With so many mutations to its genetic material, the virus can no longer survive and succumbs to ‘error catastrophe.
a. Give three (bio)chemical reasons why ‘modern' organisms (i.e. not viruses) use DNA for their genetic information storage material instead of RNA.
b. Why would ribavirin's ability to interact with both cytosine and uracil lead to high rates of genetic mutation?
Calculate the initial rate of the NO reduction at 1100 K if 400.00 mg of NO and 600.00 mg of H2 are confined to a 5.00 L reaction vessel.
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a rectangular block of plastic, measuring 1.50 cm by 2.29 cm by 1.84 cm, floats in the middle of the Pacific Ocean. The volume of sea water displaced by the plastic block is 5.46 cm3. Assuming the density of the sea water is 1.025 g/mL, what is th..
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Determine the final temperature achieved in this expansion, and the corresponding work done by the gas for the cases that it is 1) Helium, 2) Krypton.
One significant breakthrough in the study of the immune system was the development of monoclonal antibodies. State what these are, how they are made
A new potential heart medicine, code-named X-281, is being tested by a pharmaceutical company, Pharma-pill. As a research technician at Pharma-pill, you are told that X-281 is a monoprotic weak acid,
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