Explain how mutagen induces the damage

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Reference no: EM1389882

1. For each of the following mutagens, indicate what type of mutation will be induced. Also, describe how the mutagen induces the damage.
(i) Acridine orange
(ii) Ethyl Methane Sulfonate (EMS)
(iii) 2-amino purine (2AP)
(iv) aflatoxins
(v) UV light
2. Which of the following mutagenic agents do not cause transition mutations?
a) Alkylating agents
b) Base analogs
c) Aflatoxins
d) UV light
e) Acridine orange
3. Which of the following enzymes is directly involved in base excision repair mechanism of mutations?
Glycosylases
Cyclic Adenosine Monophosphate
Serines Kinases
Helicases
Alkytransferases
4. Shown below is a list of types of repair systems or repair molecules (a-g) and types of DNA damage or mutations (1-6). On the blank line following each type of damage, write the letter(s) of all repair systems that can repair (or play a role in the repair of) that particular type of damage.
a) Photolyase
b) Base-excision repair
c) SOS repair
d) Alkyltransferases
e) Mismatch repair
f) Homologous recombination
g) Nucleotide-excision repair
1) Alkylation of G residues __________
2) Trinucleotide repeat expansion__________
3) Depurination __________
4) Pyrimidine dimers __________
5) Deamination __________
6) Double-stranded breaks __________
5. Which of the following repair pathways do not involve the use of a homology-dependent repair system?
Base excision repair
Photo reactivation repair
Transcription coupled repair
Nucleotide excision repair
Mismatch repair

Reference no: EM1389882

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