Explain competitive inhibitors of a particular enzyme

Assignment Help Chemistry

Reference no: EM13211486

Company XYZ has been developing competitive inhibitors of a particular enzyme, flipase. Flipase has a k2 = 980/sec and Km = 1.2 mM.

The previous best inhibitor is drug candidate AAA, with a Ki value of 10^-6 M. The following data has just come in from the lab for a modification of the same drug candidate, BBB.

[Flipase] = 0.1 mM
[S0] = 5 mM
[BBB] = 0.01 mM
Rate observed with inhibitor, v = 5.6 x 10^-3 M/sec.

Is the new drug candidate (BBB) better than the old one (AAA)?

Reference no: EM13211486

Questions Cloud

Midlands acquisition of shipley wireless identify : What special asset does Midland's acquisition of Shipley Wireless identify? How should Midland Telecom account for this asset after acquiring Shipley Wireless? Explain in detail.

How to carried out a radical chlorination reaction : Assume that you have carried out a radical chlorination reaction on (R)-2- chloropentane and have isolated (in low yield) 2,4-dichloropentane.

State a heat exchanger is used to transfer heat from a steam : A heat exchanger is used to transfer heat from a steam stream to a chlorine gas stream. 100 kg of steam at 1 bar and 200°C enters the heat exchanger and leaves the exchanger as saturated steam at 1 bar. Chlorine gas enters the exchanger at 1 bar a..

Explain what is the maximum fermenter diameter : What is the maximum fermenter diameter that can support heat removal from a culture growing at 16 degrees Celcius with an oxygen uptake rate (OUR) of 200 mM/L/hr when cooling water

Explain competitive inhibitors of a particular enzyme : The previous best inhibitor is drug candidate AAA, with a Ki value of 10^-6 M. The following data has just come in from the lab for a modification of the same drug candidate, BBB.

State a standard na solution with a concentration : A standard Na solution with a concentration of 1.75 ?g/mL Na is added to an unknown concentration of Na. Based on the data below, determine the original concentration of Na as well as its uncertainty in a pure unknown sample.

Explain cyclotron resonance mass spectrometry : Fourier transform ion cyclotron resonance mass spectrometry yields the highest resolution mass spectra. As an example of the high resolution attainable by this technique

Vibrational modes are ir active and which are raman active : Use the character table to derive which vibrational modes are IR active and which are Raman active

State the size and ionization of energy of mercury : What will be the effect of f electrons not sheilding completely on the size and ionization of energy of mercury? Use calculations for illustration if needed

User Account

All Pages