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Eighteen blood and 14 tissue and fluid samples were taken at autopsy 16 h after the death of a 34- year-old female.Amitripyline was found in her room.Ranges of drug concentrations in blood were amitriptyline1.8 to 20.2 micrograms/mL,nortriptyline 0.6 to 7.3 micrograms/mL,levels were lowest in femoral vein and highest in pulmonary vein blood. why was nortripyline measured here? was there post-mortem redistribution? Explain.Were amitriptyline and nortriptyline over the toxic dose? Acute overdose/rapid death or chronic administration/show death? Explain
Show all the steps in the mechanism for the following reaction, When benzene is mixed with deuterated sulfuric acid, deuterium is slowly incorporated onto the ring. Show the mechanism for this reaction and explain how this relates the sulfonation of ..
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