Examine the knudson two-hit hypothesis

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Reference no: EM133178514

Biosciences and Chemistry

Cellular and Molecular Basis of Cancer

Question 1. Interpret the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting. In answering this question, give examples of proteins that promote this process.

Question 2. To what extent are the pRb and p53 pathways inter-related? In answering this question, explain the normal functions of these pathways, and highlight the mechanisms resulting in their inactivation.

Question 3. Examine the Knudson Two-Hit hypothesis in relation to hereditary cancers. In answering this question, outline three hereditary cancers, giving an overview of the gene function, and explain how the presentation of hereditary cancers differs from sporadic cancers.

Question 4. Summarise the main immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy.

Question 5. Evaluate the histopathological grading of solid tumours. In answering this question, use specific examples to relate both cellular changes and changes in tissue architecture to prognosis and disease progression.

Reference no: EM133178514

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