Evaluate the pharmacophores for better drug candidates

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Reference no: EM133676633

Few advances have been made in regards to drug development in general intravenous anesthetics. A publication in the British Journal of Anesthesiology compared the pharmacokinetic and pharmacodynamic properties of 14 intravenous general anesthetics to evaluate the pharmacophores for better drug candidates. Read the article "Comparative molecular field analysis to derive pharmacophore maps for disposition parameters of intravenous anesthetic agents." and explain in detail the following terms:

a. Comparative molecular field analysis (CoMFA)

b. Apparent volume of distribution

c. Leave-one out validation and mCV4 q2

Explain in detail the conclusions that the authors reached and how it may benefit in the development of new general anesthetics.

Reference no: EM133676633

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