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Ethics and statistics in randomized clinical trials

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Reference no: EM132843503

1. Read the Article "Ethics and Statistics in Randomized Clinical Trials ", by Richard M. Royall.

2. Answer ALL OF the following questions. One or two well-thought-out paragraphs is sufficient for each answer. Yes / No answers are not sufficient. Refer to the article.

Question 1, regarding the Personal Care Principle:

What is the Personal Care Principle?

Do you believe that a physician should provide the care to patients that is the best in his/her opinion, or only that care which has been proven most effective by scientific evidence?

Question 2:

Do you support the utilitarian argument for randomized clinical trials? That is, is it ok for a few people to suffer for the greater good of humanity?

Question 3:

What is informed consent?

Do you believe that informed consent absolves those implementing the trial of moral responsibility?

Question 4:

Do you agree with the randomized consent design, which states that consent is not needed for the standard treatment even if a potentially better treatment exists?

Question 5:

What is a response adaptive trial?

Do you believe that response adaptive trials are ethical? Should a subject entering a trial late be assigned to a treatment for which there is mounting evidence against its effectiveness, even if the probability is small?

Reference no: EM132843503

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