Estimated antibody reportoire of 1011

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Reference no: EM132501972

Each of us has an estimated antibody reportoire of 1011. That is 1011 different antibody molecules!!

Before we discovered how this challenge is met, there were two schools of tought:

1.The germline theory suggested that there was a distinct gene for each of the antibody-coding strands.

2.The diversification theory suggested that antibodies are encoded by a limited number of genes that somehow are diversified.

The discovery that the haploid human genome contains roughly 3 billion bases made one of these theories untenable.

Question: calculate the number of immunoglobulin genes that can fit in the haploid human genome. Which of the theories is more plausible?

(note: you will have to make some assumptions in reaching your answer. The thought process is what matters!).

Reference no: EM132501972

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