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Question: Background and Purpose-The efficacy and safety of different antiplatelet regimes for stroke prevention in patients at high risk were investigated in a systematic review and meta-analysis. Methods-We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Web of Science. Twenty-two studies comprising 173371 patients were included.
Results-In the overall population, dual antiplatelet therapy (DAPT) with aspirin and clopidogrel in comparison to aspirin monotherapy reduced the relative risk of total stroke by 20% (risk ratio [RR], 0.80; 95% confidence interval [CI], 0.73-0.88; P<0.0001; I2 =28%) and of ischemic stroke or transient ischemic attack by 23% (RR, 0.77; 95% CI, 0.69-0.85; P<0.0001; I2 =18%) without increasing the risk of intracranial haemorrhage. In the secondary prevention cohort, DAPT with aspirin and clopidogrel also reduced the relative risk of total stroke by 24% as compared with aspirin alone (RR, 0.76; 95% CI, 0.68-0.86; P<0.0001; I2 =0%). DAPT with prasugrel or ticagrelor and aspirin versus DAPT with clopidogrel and aspirin was not associated with a stroke risk reduction.
Conclusions-DAPT with clopidogrel and aspirin compared with aspirin effectively reduces the risk of total and ischemic stroke in the overall cohort consisting of patients with cardiovascular disease without an increase in intracranial haemorrhage, as well as
Using the Born-Mayer-Huggins form of the potential energy, calculate the lattice energy v(r_0) for Ba0 (Rocksalt crystal structure) using only nearest neighbor repulsions. Given the equilibrium constant (separation) r_0=2.77 angstrom.
For this assignment, write an essay that examines medical records and the Health Insurance Portability and Accountability Act (HIPAA). Address the following.
Develop a thesis that summarizes what the film is telling the viewer about how social actors attempt to resolve their ethical concerns.
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Describe in your own words, the role that water plays to help regulate Earth's climate. Be as specific as possible.
"Think of a major problem from your own life (or someone else's) that involved the discovery of one or more hidden assumptions.
Identify and discuss the strategic objectives of the organisation - Include an analysis of the contextual factors and potential ‘strategic alliances' for your organisation, specific to the ‘general and task environments'.
Consider any important and controversial current issue in public policy.
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The GM has narrowed the choices to two: large facility or small facility. The company has collected information on the payoffs.
In those paragraphs, you will write what protocols you would have put in place if you were in charge of security for the organizations mentioned in the article.
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