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Changes in genetic sequences, or mutations, can result from various types of damage. The damage may be minor to extensive alterations in the DNA. Correspondingly, mutations may result in no phenotypic change or in phenotypic changes ranging from minor with little impact on fitness to severe enough to destroy a gene product and compromise an organism's ability to survive.
Part A - The effects of point mutations on polypeptides
Point mutations are those that alter a single base pair or base location, and include substitutions and frameshift mutations. They can range in severity from no phenotypic change to complete loss of function.
Rank the following point mutations in order of least damaging to most damaging if they occur in the middle of the coding sequence of a polypeptide.
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