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Effects of engaging the t cell receptor

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Many of the effects of engaging the T cell receptor with MHC-peptide can be duplicated by the administration of ionomycin plus a phorbol ester. Ionomycin is a Ca2+ ionophore, a compound that allows calcium ion in the medium to cross the plasma membrane and enter the cell. Phorbol esters are analogues of diacylglycerol (DAG). Why does the administration of phorbol and calcium ionophores mimic many effects of T cell receptor engagement?

Reference no: EM132742554

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