Drug content of a standard solution

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Statistic Question 1

A UV-vis method is regularly used to determine the drug content of a standard solution giving an average of 450 mg / 100 ml

As part of the quality control process the standard was analysed 6 times, the results for the concentration (mg/dm3) were 460, 450, 472, 460, 464, and 465.

Are these results within the accepted range with 95% confidence?

What can be concluded from the latest set of results?

(16.7% total marks)

Statistic Question 2

The absorption of a drug through skin from two different formulations was investigated using 6 samples of each formulation.

A Franz cell was used with fresh skin for each analysis, the concentrations of the drug in the collecting vessels are tabulated below.

Formulation A/ ppm

21

21

24

26

27

27

Formulation B /ppm

18

23

23

25

25

27

Use suitable statistical tests to compare the results from the two formulations.

If the results for a third formulation also needed to be compared, which statistical test would need to be used?

Reference no: EM131064457

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