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Question - Toll-like receptors (TLRs) are immunoreceptors responsible for the detection of pathogen-derived molecules. Human TLR4 is a membrane protein with an N-terminal extracellular domain and a C-terminal cytosolic domain connected by a single transmembrane a-helix. The sequence of the transmembrane helix is IIGVSVLSVLVVSVVAVLVY. Estimate the thickness of the cell membrane according to structural features of the a-helix. Draw a simple cartoon figure of TLR4 with the a-helix embedded in the membrane and explain why this a-helix is rich of hydrophobic residues. (The cartoon of the a-helix should show the correct length and handedness of the a-helix).
Show all the steps in the mechanism for the following reaction, When benzene is mixed with deuterated sulfuric acid, deuterium is slowly incorporated onto the ring. Show the mechanism for this reaction and explain how this relates the sulfonation of ..
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