Reference no: EM1389690

1) Determine what kind of DNA mutation in a gene would result in the production of a shorter version of a protein missing amino acids in the middle of the protein, but beginning and ending with the same amino acids found int he wild type protein?
a) an anticodon mutation
b) an insertion that adds a number of nucleotides that is some multiple of
three
c) a deletion that removes a number of nucleotides that is some multiple of
three
d) a frameshift mutation
e) a nonsense mutation
2) Which of the following domains is found in the GAL80 protein?
a) DNA binding domain
b) transcription activation domain
c) GAL4 binding domain
d) two of the above
e) all of the above
3) A positive result in the Ames test indicates that the tested chemical is a mutagen. A positive test
results in
a) break down of a mouse liver extract
b) death of the mouse
c) production of bacterial auxotrophic mutant strains
d) reversion of a bacterial auxotrophic mutant strain
e) reversion of a bacterial prototrophic mutant strain
4) The Fragile X syndrome is caused by trinucleotide repeat expansion. The repeated nucleotides
are CGG, and in affected individuals the CGG repeat region is found to be methylated at CpG
residues. Knowing this, which of these best describes the likely genetic behavior of Fragile X
Syndrome?
a) maternal effect lethal
b) autosomal recessive
c) X-linked recessive
d) X-linked dominant
e) autosomal dominant
5) You are engaged in the study of a gene, the transcription of which is activated in muscle cells by
glucocorticoid. From cultured muscle cells, you are able to isolate mutant cells in which the gene
no longer responds to glucocorticoid. What is a possible explanations for why these cells no
longer resond to hormone?
a) a nonsense mutation in these cells leading to production of a truncated
version of RNA polymerase II
b) a gain-of-function mutation in these cells leading to production of a
constitutively active glucocorticoid receptor
c) a mutation in these cells that deletes the glucocorticoid response element
from upstream of the target gene
d) a loss-of-function mutation in these cells leading to production of a
defective enzyme required to synthesize glucocorticoid
e) none of the above