Discuss the role of the respiratory system

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Reference no: EM132424974 , Length: word count:3000

Assignment -

Please choose one essay title for each part and write your answers for each question as a 1500 words essay. Your work will thus comprise two parts of 1500 words, and the whole course work will be 3000 words.

Part A -

Option 1 - Discuss the role of organellar quality control in maintaining mitochondria homeostasis and how its impairment may contribute to disease.

Option 2 - Discuss the role of the respiratory system in maintaining cellular function and how its dysfunction may contribute to disease.

Part B -

Option 1. How can gene and cell therapy tackle infectious diseases?

To get started, refer to Hoxie & June (2012) Novel cell and gene therapies for HIV. Cold Spring Harb Prespect Med. doi: 10.1101/cshperspect.a007179.

Please also extend your reading to other reviews and articles for a wider perspective to your essay.

Option 2. Personalised gene and cell therapies are not sustainable treatment options against rare inherited diseases. Discuss.

To get started, refer to Kim et. al. (2019) Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. doi: 10.1056/NEJMoa1813279.

Please also extend your reading to other reviews and articles for more details in your essay.

Part C -

Option 1 - The targeted use of biologics and synthetic DMARDs such as Baricitinib will improve the treatment of psoriatic arthritis.

Provide a critical discussion of this statement.

Option 2 - Critically evaluate the role of cyclin-dependent kinases 4/6 inhibitors in cancer therapy.

Reference no: EM132424974

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