Reference no: EM133092099
CHT206 Structure and Mechanism in Organic Chemistry
Question: apply MO theory in the analysis of organic reactivity;
Question: classify pericyclic processes;
Question: predict the outcome of pericyclic processes, including periselectivity, regioselectivity and stereoselectivity;
Question: critically discuss techniques for acquiring kinetic data;
Question: discuss the analyseis of kinetic data in terms of mechanistic models;
Question: describe critically discuss the underlying physical basis for, and applications of, of kinetic isotope effects and interpret kinetic isotope effects in terms of possible reaction mechanisms;
Question: describe critically discuss the underlying physical basis for, and applications of,of isotopic labelling studies and interpret the result of labelling studies in terms of possible reaction mechanisms;
Question: critically discuss the determination of activation parameters and how these are interpreted activation parameters in terms of reaction mechanisms;
Question: critically discuss the physical basis of linear free energy relationships and apply in critical analysis of reaction mechanisms;
Question: propose a falsifiable reaction mechanism for a reaction based on physical data and MO analysis.
Question: critically discuss the use of kinetic, thermodynamic and mechanistic information in the optimisation and scale up of reactions
Intellectual Skills
Question: integrate previously acquired knowledge of reactivity patterns in organic chemistry with experimental and computational data to solve problems of organic reaction mechanisms;
Question: apply retrosynthetic analysis to problems featuring pericyclic processes.
Question: evaluate whether a reaction mechanism is reasonable or not through an analysis in terms of frontier molecular orbital theory;
Question: propose reaction intermediate(s) and products for pericyclic reactions;
Question: evaluate whether a reaction mechanism is reasonable or not through an analysis based on the prediction of the relative thermochemistry of intermediates and molecular orbital interactions;
Question: propose reasonable reaction mechanisms based on provided data.