Reference no: EM133092099

CHT206 Structure and Mechanism in Organic Chemistry

Question: apply MO theory in the analysis of organic reactivity;

Question: classify pericyclic processes;

Question: predict the outcome of pericyclic processes, including periselectivity, regioselectivity and stereoselectivity;

Question: critically discuss techniques for acquiring kinetic data;

Question: discuss the analyseis of kinetic data in terms of mechanistic models;

Question: describe critically discuss the underlying physical basis for, and applications of, of kinetic isotope effects and interpret kinetic isotope effects in terms of possible reaction mechanisms;

Question: describe critically discuss the underlying physical basis for, and applications of,of isotopic labelling studies and interpret the result of labelling studies in terms of possible reaction mechanisms;

Question: critically discuss the determination of activation parameters and how these are interpreted activation parameters in terms of reaction mechanisms;

Question: critically discuss the physical basis of linear free energy relationships and apply in critical analysis of reaction mechanisms;

Question: propose a falsifiable reaction mechanism for a reaction based on physical data and MO analysis.

Question: critically discuss the use of kinetic, thermodynamic and mechanistic information in the optimisation and scale up of reactions
Intellectual Skills

Question: integrate previously acquired knowledge of reactivity patterns in organic chemistry with experimental and computational data to solve problems of organic reaction mechanisms;

Question: apply retrosynthetic analysis to problems featuring pericyclic processes.

Question: evaluate whether a reaction mechanism is reasonable or not through an analysis in terms of frontier molecular orbital theory;

Question: propose reaction intermediate(s) and products for pericyclic reactions;

Question: evaluate whether a reaction mechanism is reasonable or not through an analysis based on the prediction of the relative thermochemistry of intermediates and molecular orbital interactions;

Question: propose reasonable reaction mechanisms based on provided data.