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Question 1 - For a new investigational drug product, the estimation of the first dose to be used in humans is usually derived from nonclinical studies. Please propose a nonclinical study design that would be conducted for the determination of the first-in-human dose for an investigational drug product.
Question 2 - Elaborate on the challenges associated with the use of animal models in nonclinical studies for the development of biologics products as compared to small molecule drug products
Question 3 - Discuss on the importance of phase IV clinical trials in the development of medicinal products for human use.
Draw the structure of the 4 possible ionization states of tyrosine and calculate the net charge for each state. Draw the titration curve for Tyrosine. The pKa of the carboxylic acid = 2.20. the pKa of the amino group is 9.20.
Use the Nernst equation and data from Appendix D to calculate Ecell for each of the following cells. Enter your answer with 3 significant digits. Enter scientific notation as 1.23E4.
write a balanced chemical equation for the reaction mg hcl. given that 1 mole of mg produces 1 mole of hydrogen h2 what
What does the lewis structure for the conjugate acid of CH3OCH3 look like? include reosnonce
question how long does it take a person at rest to breathe one mole of air if the person breathes 80.0mls of air that
Calculate the pH of the solution after the addition of 100mL of 1.00 M HCL. the Ka for Hf is 3.5*10-4
A 9m^3 room contains a canister of CO2 with a faulty valve. At a level of 75 mole % CO2, breathing the air becomes lethal. The room temperature is 25 degrees Celcius.
When a volcano erupts, 175g of steam at 100°C is released. How many kilojoules are lost when the steam condenses, cools, freezes, and cools to -5°C.
To ensure that do not provide customers with substandard product, the local steel mill has instigated a quality control program using flame AAS. two of the trace elements they wish to monitor, Al and Ti, form stable oxides
Hydrogen bonding between polyamide chains plays an important role in determining the properties of a nylon such as nylon 6,6 (Table 12.2) Draw the structural formulas for two adjacent chains of nylon 6,6 and show where hydrogen-bonding interaction..
Give the structures of two different aromatic compounds that could be used to synthesize benzene-1,2-dicarboxyclic acid
What is the pressure of a 10g sample of sulfur trioxide in atmospheres at a temperature of 20 degrees Celsius that has a volume of 50L
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