Differences in resistance between the two strains to azoles

Assignment Help Biology

Reference no: EM1385470

Suppose you are studying a new fungal pathogen Candida ickius that is highly resistant to the azole class of antifungals and you note that there is an efflux pump, Pmp-1, that appears to be at very high levels in the cell membrane; this is unlike the very genetically similar organism Candida noticky which is sensitive to the azoles and has low levels of Pmp-1 in its membrane (as determined through comparative western blotting). You also recall that Dr. I.M. Theman published that pmp-1 is transcriptionally repressed by Not-1. Western analysis of Not-1 in both Candida ickius and Candida noticky indicates that Not-1 is expressed much less in C. ickius.

How may this impact drug resistance in C. ickius versus C. noticky? How would you design experiments to explain the differences in resistance between the two strains to the azoles?

Reference no: EM1385470

Questions Cloud

What you have researched and studied throughout modules : Using what you have researched and studied throughout Modules 1 - 7, write a report addressing a quantitative analysis (QA) project

Determine the design hourly volume for the road : Determine the design hourly volume for the road below, recommend the K factor first. a. For a two lane highway in a national park with AADT of 10,000 vpd.

Etec co mingling with shigella : Suppose you have an ETEC strain of E. coli and you noted that in a contaminated water source that there are ETEC and Shigella species.

Discuss the concept of worldview : Using the Theism worldview, the learner is to discuss the concept of worldview and its application to business. Briefly discuss the concept of worldview and present an argument for the application of this concept to business leadership.

Differences in resistance between the two strains to azoles : Suppose you are studying a new fungal pathogen Candida ickius that is highly resistant to the azole class of antifungals and you note that there is an efflux pump.

Calculate the mass emissions rate : Assuming that the average stack gas velocity is 10.0m/s and the stack is circular with a 3.0 meter diameter, calculate the mass emissions rate of NO2 in kg/day.

Identify three of the product types : Identify three of the product types that are primary moved using the five modes of transportation

Means-ends and consequences : Suppose you're a police officer assigned to drug task force. Considering the principle of "ethical egoism," take a position for or against the practice of planting evidence or holding back evidence to aid make sure the conviction of known drug tra..

Surface area of the lagoon : If the evaporation rate from an open water surface is 0.27 inch/day in Tucson Arizona, what should be the surface area of the lagoon? (Note: arsenic does not evaporate but remains in the liquid water).

User Account

All Pages