Determine which mutant forms a misfolded structure

Reference no: EM1395136

The flipping of Phe rings requires that groups surrounding the ring move aside momentarily. The rate of ring flipping can be measured using NMR. You are studying two mutant versions of a protein. In both of the mutants, the proteins have considerable secondary structure, based on circular dichroism studies, and bind the hydrophobic dye ANS, indicating the formation of the hydrophobic core of the protein. However, in one of the mutants (mutant A), the rate of Phe ring flipping is much higher than in the other (mutant B). A researcher suggests that one of these mutants completes the folding process to form a misfolded protein, much like a prion, whereas the other is stuck at some point on the folding pathway.

A. Which mutant forms a misfolded structure? Explain your reasoning.

B. Where along the folding pathway is the other mutant stuck? Again, explain your reasoning.

Reference no: EM1395136

Questions Cloud

What is the phase of neon at room temperature : Neon(Ne) is a noble gas with atomic number 10 this is a odorless, colorless, inert monatomic gas under standard conditions but explain some facts about Neaon.

Test the hypothesis-producing the same mean : Use an alpha level of .01 and test the hypothesis that the two methods are producing the same mean.

Determine what would be the total ?nal pressure : Determine what would be the total ?nal pressure of the system in atmospheres If we completely hydrolyzed 0.18 kg of H2O in a 8.2 L container at 300 K?

Sampling distribution-proportion of first-time customers : The president of Doerman Distributors, Inc., believes that 30% of the firm's orders come from first-time customers. A random sample of 100 orders will be used to estimate the proportion of first-time customers. Assume that the president is correct..

Determine which mutant forms a misfolded structure : The flipping of Phe rings requires that groups surrounding the ring move aside momentarily. The rate of ring flipping can be measured using NMR.

Calculate the density of a block : Calculate the density of a block.

Write a two-page memorandum regarding the ethical rules : Write a two-page memorandum regarding the ethical rules in your state regarding a law firm's duty to safeguard client information that is stored electronically

Why bromine is larger than chlorine : This is a fact that Bromine(Br) is larger than chlorine(Cl) but indication of equilibrium constant suggests that a bromo substituent has a less preference for the equatorial position than chloro substituent? Explain it briefly?

Department store sales-sample distribution analysis : A random sample of 81 credit sales in a department store showed an average sale of $68.00. From past data, it is known that the standard deviation of the population is $27.00.

User Account

All Pages