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Question: Determine the significance of the observation that knocking out MyD88abrogates increases in Factor B and C3a but knocking out of TRIF does not? Describe in molecular terms.
Question: From these experiments can you determine the types of pathogens that caused sepsis in these mice? What are the most likely activating TLR ligand(s)? Explain and justify your answers to these two questions.
Question: What do these results suggest about the role of complement in septic shock? Which complement pathway is involved and at what step(s) of complement activation is regulation by TLR having its effect? Identify the key molecules and cells in the septic inflammatory response that are affected by complement activation and explain their role in sepsis.
Question: Why are C3a and Ba still present in sera from MyD88-/- mice?
Question: Why is it that the researchers cannot measure C3b in sera from the sepsis-induced mice?
An assured drug that is used to control high blood pressure stimulates K+ excretion in the kidney such that plasma [K+] decreases from a normal value of 5 mM to 2.5 mM. Intracellular [K+] is largely unaffected. What effect this drug will have on the ..
Explain the general function of Respiratory system and describe how the Respiratory system contributes to the physiological homeostasis of human organism?
The molecules of all matter, particularly gases and liquids, are in constant vibration motion. As a result of this motion, molecules are continually colliding with one another, much like balls scattering over a pool table.how to Add a coverslip ov..
Beaker A contains 25 percent salt solution. A differentially permeable bag (permeable to water not salt) containing 50 percent salt solution is allowed to float on top of the solution in Beaker A. What will occur.
Distribute copies of the passage. Begin the passage and the idea of using thinking strategies to identify the main idea. Today, were going to identify the main idea of a passage. What are we going to do.
What kind of approach is this alien taking to learn about the car? An alien from a new planet landed on earth. He is attentive by cars and is determined to figure out how they work.
Animals obtain energy during a sequence of chemical reaction in which sugar (C6H12O6) and oxygen gas (O2) are reactants. This process produces water (H2O) and carbon dioxide (CO2) as waste products. How might you use radioactive isotope to find out w..
You want 1 L of 100 mu M NaCl, and you have 1 M stock solution. How much of the stock solution and determine how much dH2O will you measure out for this dilution?
If NAD+ is an electron acceptor that becomes NADH and the NADH then donates a proton to ATPase, should not NADH now become NAD- since it lost it's proton but still has electron?
Why was the discovery of microsphere and coacervates an important contribution to understanding of how life might have originated on earth .
In examining a picture of the cell taken with an electron microscope, a student observes that the cell has a nucleus and a cell membrane but not a cell wall. The student can accurately conclude that the cell is a what.
You have T cells that can respond to antigen A. Your spouse does not have T cells that respond to antigen A, so you offer to transfuse some of your T cells to your spouse. Why wouldn't it work? Be very specific.
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