Determine the osmolarity of resulting solution

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Reference no: EM1381656

The osmolarity of human plasma is normally 290 milli-osmoles per liter (0.29 Osmolar). Use a value of 300 milliosmoles/liter (300 mOsM) in solving the problems below.

1. A drug that does not dissociate has a molecular weight of 300. If 300 g of this drug are dissolved in 1000 ml of water, what is the osmolarity (in Osmols/liter or mOsmols/liter) of the resulting solution?

2. A drug has a molec. weight of 200. How many grams would you use to make 100 ml of a solution that is isotonic (for man)? Assume that the diluent is distilled water and that the drug does not ionize in water.

3. Percent solutions are made on the basis of g/ml or ml/ml of diluent, and it is usually assumed that 1 ml of water = 1 g of water. For example, 20 g/100 ml of water or 200 g/1000 ml of water = a 20 % solution. If a 60 % solution of a substance (molec. wt. of 150) is infused intravenously (i.v.) into a patient, what will happen to the red blood cells at the site of infusion? Explain your answer in terms of the osmolarity of the solution. Assume that the substance does not ionize.

4. Calculate the osmolarity of a solution of 5% dextrose in water (dextrose = glucose, molec. Wt. = 180).

5. If the osmolarity of plasma (inside a capillary) is 300 mOsM, the osmolarity of the tissue fluid (interstial fluid) is 400, and the membranes are permeable to water but not to salts or proteins, in which direction will water move (from the capillary into the tissue or from the tissue into the capillary)? If the lymphatic vessels remove proteins from the interstitial fluid, will the osmolarity of the interstitial fluid increase or decrease?

Reference no: EM1381656

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