Reference no: EM131917119

Sotalol is a drug with beta-blocker and antiarrhythmic actions. The kinetics of the metabolism of the drug were followed by determining the concentration of the remaining non-metabolised sotalol at different times as tabulated in Table 1 below.

Table 1: concentration of non metabolised sotalol as function of time.

Time/ h 0 10 20 30 40 50 60

[Sotalol]/mM 2.00 1.26 0.80 0.50 0.32 0.20 0.13

a) Determine the order of the reaction using appropriate plots and discussion.

b) Calculate the rat constant showing all your working.

c) Calculate the half- life graphically and analytically (numerically).