Determine if each change would cause a gain-of-function

Reference no: EM133434482

Question: Determine if each change would cause a gain-of-function or a loss-of-function in the following genes:

1. A chromosomal translocation that puts a tumor suppressor under the control of a widely expressed promoter.

2.A translocation of a proto-oncogene that creates a hybrid protein that is always on (with the same role as the original proto-oncogene)

3.Amplification of a tumor-suppressor gene

4.A point mutation that causes a proto-oncogene to no longer be functional

Which of the previous scenarios would most likely be a first "hit" in the development of cancer? Why?

Reference no: EM133434482

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