Designed to measure the partition coefficient

Reference no: EM13538158

An experiment is designed to measure the partition coefficient, K, associated with the transfer of a pharmaceutical product through a polymer material. The partition coefficient is defined as the ratio of the densities of the species of interest (the pharmaceutical) on either side of an interface. In the experiment, liquid pharmaceutical ( \(\rho=1250 kg/m^3\) ) is injected into a hollow polymer sphere of inner and outer diameters Di= 5mm and Do= 5.1mm, respectively. The sphere is exposed to convective conditions for which the density of the pharmaceutical at the outer surfaces is zero. After one week, the sphere's mass is reduced by \(\Delta M= 8.2 mg\) . What is the value of partition coefficient if the mass diffusivity is Dab= 0.2*10^-11 m^2/s?

Reference no: EM13538158

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