Describing margination-diapedesis-migration and chemotaxis

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Angela M, a 28-year-old middle school teacher, is brought to the urgent treatment center by her husband with complaints of fever, chills, and a productive cough of 2 days' duration. Following appropriate evaluation, she is diagnosed with right lower lobe pneumonia. Her husband, Mark, is currently recovering from cancer chemotherapy for treatment of Hodgkin disease. His most current complete blood cell count shows evidence of moderate bone marrow depression.

  1. Assuming that Angela has an intact immune system, describe neutrophils and explain their role in destroying her bacterial pneumonia.
  2. In order to combat Angela's pneumonia, the immune cells have to be able to move to the site of the infection.

Explain how this is accomplished by describing margination, diapedesis, migration, and chemotaxis.

  1. As the nurse is interviewing and assessing Angela, do you have any concerns about her husband, Mark?
  2. While you are interviewing Angela, Mark asks you to give him some advice. He tells you that he has been having frequent nosebleeds that are difficult to stop. Considering his recent history, why might he be having epistaxis (nosebleeds)?
  3. Assume for a moment that Mark has thrombocytopenia. Briefly describe the role of platelets in hemostasis.

Reference no: EM133242871

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