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Describe the steps in parasympathetic neurotransmission

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To help relieve the pain caused by swelling and inflammation of her eye, Barb has been prescribed medication to dilate her pupil. She notes that the medication she has been given targets parasympathetic neurotransmission.

Question (a) Describe the steps in parasympathetic neurotransmission in the eye, highlighting the transmitter involved and receptor type present.

Question (b) Describe the effect of parasympathetic nerve stimulation on the pupil and the likely mechanism of action of the medication Barb has been prescribed. Indicate the site of action of the medication.

The product Information indicates that although "side-effects of this medication are unlikely" they could include dry eyes; dry mouth; dry skin and increased heart rate.

Question (c) Explain why these side-effects might occur.

Barb's medication has a half-life of 9hrs, is eliminated via 1st order kinetics and has a volume of distribution of 1.5L/kg.

Question (d) Identify the body compartment the drug is most likely to distribute into and list 2 properties of the drug that would lead to this distribution. Estimate, in hours, how long you would you expect elimination of the drug to take (i.e. <10% dose remaining)?

 

Reference no: EM133517938

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