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Briefly describe the significance of each of the following molecules, their relationship with one another and the overall potential effects on transcriptional regulation (in eukaryotes). Identify whether each molecule is a protein or DNA sequence:
a) How a gene gets up-regulated: enhancer element, activator, repressor element, inhibitor, promoter, general (basal) TF's, RNA polymerase.
b) How a gene gets down-regulated: enhancer element, activator, repressor element, inhibitor, promoter, general (basal) TF's, RNA polymerase,
c) Briefly describe the potential role that DNA bending protein and mediator proteins play in regulation.
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Assume a population of people is 16% Rh - negative.
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