Describe the pathophysiology of depression

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Question 1: Describe the pathophysiology of depression.

Depression affects millions of people around the world each year. This disorder is many times masked due to the stigma that comes with depression. Depression is defined as an emotional state, sadness that becomes chronic and uncontrolled. Major depression consist of depressed mood, loss of interest or pleasures, changes in activity, guilty or feeling worthless, wish one was death or having thoughts of suicide, fatigue or loss of energy, decreased concentration and changes in sleep pattern, appetite or weight (McCance & Huether, 2019 p. 605). Major depressive disorder is the most common mood disorder and the leading cause of disability in the U.S. Studies have shown that people with a family history can be more at risk for having depression than someone that has no family history.

Below are factors that can influence depression:

  • Genetic Predisposition and Environmental Influences
  • Neurochemical Dysregulation
  • Neuroendocrine Dysregulation (Stress)
  • Neuroanatomic and Functional Abnormalities
  • The Glutamate system

Reference no: EM132896513

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