Describe the macrophage feed-forward loop

Reference no: EM133610743

Question

Arrange the items in order to describe the macrophage feed-forward loop present in the intestines when a pathogen breaches the epithelial barrier. Start by clicking the first item in the sequence or dragging it here Monocytes are recruited from the blood and differentiate into inflammatory macrophages. Increases in pro-inflammatory cytokines lead to large alterations of the local environment around the infected mucosa, recruiting inflammatory cells from the blood. PAMPs activate pattern-recognition receptors in epithelial cells, leading to the release of IL-1β and IL-6. Inflammation-anergic resident macrophages sense pro-inflammatory cytokines and release CXCL8 and CCL2.

Reference no: EM133610743

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