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A genetic mutation occurs that alters the specificity of the Golgi enzyme that phosphorylates mannose residues in the oligosaccharides of glycoproteins. The effect of the mutation is such that the enzyme now indiscriminately and randomly phosphorylates mannose residues on all glycoproteins passing through the Golgi complex.
A. What is the normal role ofthis enzyme?
B. What is the normaldestination of Golgi contents that are phosphorylated on mannoseresidues and how do they get there?
C. What are the consequences ofthis mutation?
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