Reference no: EM133422698

Questions:

Describe the function of the hemoglobin protein, including what cells make hemoglobin, and the basic quaternary structure of the protein (that is, how many polypeptides made up the structure of hemoglobin).

Describe the phenotype, specifically the characters or symptoms associated with individuals who have the recessive sickle cell defect.

Cite any reference(s) used for the information included in questions 15 and 16.

Here are the codons for the first six amino acids in the normal mature beta-globin polypeptide chain. Using the genetic code, translate the first six amino acids, in their correct order, from the normal allele of the gene. You can write the three letter abbreviations used in the code.

5'- G U G C A C C U G A C U C C U G A G -3'

Here are the codons for the first six amino acids in the defective sickle cell beta-globin polypeptide chain. Using the genetic code, translate the first six amino acids, in their correct order, from this defective allele of the gene.

5'- G U G C A C C U G A C U C C U G U G -3'

State the one simple difference between the amino acid sequences of the normal allele vs. the sickle cell allele. Remember: This is the only change in all 146 amino acids of this chain, yet it causes individuals with this defect to experience all the symptoms you noted in question 16!