Describe the differences between naloxone-naltrexone

Reference no: EM133521775

Assignment:

Stahl, S. M. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.

JM is a 45-year-old female admitted with alcohol intoxication. Would like to detox. She reports a 25-year history of alcohol dependence with multiple relapses. Reports history of withdrawal seizures. Current Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-AR) is 18. She denies any past medical history. She denies taking any medications or other substance use. Her Labs are all normal except elevated LFTs.

QUESTIONS:

1. DISCUSS/EXPAIN in detail the pharmacological treatment to manage withdrawal syndrome for the case scenario.

2. DISCUSS/EXPAIN in detail AND provide your rationale, pertinent mechanism of action, and other clinical implications.

3. Describe the differences between Naloxone, Naltrexone, and Buprenorphine/Naloxone. Include the properties of each, their classification, mechanism of actions, onset, half-life, and formulations (routes of delivery).

4. DISCUSS/EXPAIN in detail the implications based on the differences in the setting of drug administration (pre-hospital vs hospital/clinical setting).

Reference no: EM133521775

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