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Describe molecular mechanisms of fertilisation

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Give definition for gametogenesis; describe origin of gametes - early migration of PGCs, epigenetic changes in PGC, formation of spermatogonia and oogonia, molecular mechanisms of sex determination and differentiation - the main genes and proteins - SRY and SOX9, their role.

Give detailed explanation of oogenesis, including proliferation, growth and maturation periods (timing, type of cells formed, type and stages of cell division, X chromosome reactivation).

Give detailed explanation of spermatogenesis, including proliferation, growth maturation and spermiogenesis periods (timing, type of cells formed, Sertoli 2 cells, spermatogonial syncytium, acrosome).

Describe molecular mechanism of abnormal spermatogenesis which can lead to human pathology (to name diseases is not requested).

Describe molecular mechanisms of fertilisation - sperm-egg recognition and binding; acrosomal reaction; fusion; cortical reaction; cleavage.

Explain / describe comprehensive understanding of gametogenesis, fertilisation and its biological role.

Reference no: EM133292902

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