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A. Why is homologous recombination between nonsister chromatids preferred?
B.Is it possible to tell whether a DNA gap was generated during a homologous recombination eent that occurs at a heterozygous locus? Why or why not?
C. Based on its structure, explain how the synaptonemal complex could actually represent an obstacle to recombination.
D. Why is it important that resolvases function as symmetrical molecules with two active sites?
E. Explain why either a single- or double-strand break can result in a change in supercoiling.
F. The Cre/lox system is used to extensively to create "conditional knockouts" in mice, for example to delete a gene of interest in a particular tissue type. Describe how such a system might work.
Do you think that using recombinant DNA technologies to change the genetic composition of human egg cell is ever justified? If so, what restrictions have to be placed on such a use.
Assume you have identified a four exon gene expressed in the nervous system of a diploid animal. Different splice variants are expressed in the nervous tissue at the same time.
State the probability (percentage or fraction) of each of following sets of parents generating the given genotypes within their offspring.
The idea is that this arrangement will allow animals and plants to migrate between refuges. Why would such migration be significant. Examine the F1 offspring from this cross.
What is estimated density of firs in the forest. Why then is the gene called Dorsal, and not, for instance, Ventral.
Glucose is frequently administered intravenonusly to patients as a food source. A new resident at the hospital suggests administering glucose-6-phosphate instead. Glucose-6-phosphate requires ATP and you consider the possibility that administering..
Acetylcholine acts at the G-protein-linked receptor on heart muscle to make the heart beat more slowly by the effect of the G protein on a K+ channel. Which one or more of next would enhance this effect of acetylcholine.
A cricket has a diploid genome of 1.2 billion base pairs. Assume that there are about 200,000 individuals in the population and that the mutation rate is one per 100 million base pairs. About how many new mutations will occur in each generation of..
Name three bodily fluids, besides blood serum, that might be used for immune testing. How do you know a reaction between specific antibody and antigen has occurred in an ELISA test
Assume if the actual AB haplotype frequency was found to be 0.5, would you conclude that the loci are linked or not?
On an autosome, genes A and B are twenty map units apart. An AABB male mates with an aabb female. Determine % of the gametes produced by their hybrid offspring will be Ab?
A bar graph is used instead of a line graph because every type of liver cell was independent of the others. Determine what variable did researchers intentionally vary in experiment, and what are the units for this variable?
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